Infliximab for treatment-refractory transverse myelitis following immune therapy and radiation.

BackgroundNeurologic toxicities with immune therapy are rare, but can cause devastating and often permanent injury when they occur. Although there is increasing interest in the potential synergism between immune therapy and radiation, it is possible that such combinations may lead to a greater number or increased severity of immune-related adverse events. We present here a case of extensive and progressive transverse myelitis following combined therapy, which did not improve until treatment with infliximab. This case highlights the unmet need for treatment of adverse events that are refractory to consensus recommendations, and may ultimately require further study and incorporation into future published guidelines.Case presentationWe report a case of a 68-year-old with metastatic melanoma, who developed transverse myelitis in the setting of immune checkpoint blockade and spinal irradiation for vertebral metastases. Despite management according to published consensus guidelines: cessation of immune therapy, high-dose steroids, and plasmapheresis, he continued to deteriorate neurologically, and imaging revealed a progressive and ascending transverse myelitis. The patient was then treated with infliximab, and demonstrated dramatic imaging and modest clinical improvement following the first treatment cycle.ConclusionsThis is the first report describing the successful use of infliximab in immune therapy and radiation-related transverse myelitis that was not responding to recommended therapy. Evaluation of additional treatment options such as infliximab for high-grade immune-related neurologic toxicities is warranted, and may be needed earlier in the disease process to prevent significant morbidity. The adverse effects of immune therapy when used in combination with radiation also require further investigation

Three-dimensional modeling of lightning-induced electromagnetic pulses on Venus, Jupiter and Saturn

While lightning activity in Venus is still controversial, its existence in Jupiter and Saturn was first detected by the Voyager missions and later on confirmed by Cassini and New Horizons optical recordings in the case of Jupiter, and recently by Cassini on Saturn in 2009. Based on a recently developed 3D model we investigate the influence of lightning-emitted electromagnetic pulses (EMP) on the upper atmosphere of Venus, Saturn and Jupiter. We explore how different lightning properties such as total energy released and orientation (vertical, horizontal, oblique) can produce mesospheric transient optical emissions of different shapes, sizes and intensities. Moreover, we show that the relatively strong background magnetic field of Saturn can enhance the lightning-induced quasi-electrostatic and inductive electric field components above 1000 km of altitude producing stronger transient optical emissions that could be detected from orbital probes

GRBs with optical afterglow and known redshift: a statistical study

We present a correlation between two intrinsic parameters of GRB optical afterglows. These are the isotropic luminosity at the maximum of the light curve (Lpeak) and the time-integrated isotropic energy (Eiso) radiated after the observed maximum. We test the correlation between the logarithms of (Eiso) and (Lpeak) and finally we value the effect of the different samples of GRBs in according with the first optical observation reduced to proper time.Comment: To be published in the proceedings of the conference "SWIFT and GRBs: Unveiling the Relativistic Universe", Venice, June 5-9, 200

ASCA and BeppoSAX observations of the peculiar X-ray source 4U1700+24/HD154791

The X-ray source 4U1700+24/HD154791 is one of the few galactic sources whose counterpart is an evolved M star. In X-rays the source shows extreme erratic variability and a complex and variable spectrum. While this strongly suggests accretion onto a compact object, no clear diagnosis of binarity was done up to now. We report on ASCA and BeppoSAX X-ray broad band observations of this source and on ground optical observations from the Loiano 1.5 m telescope.Comment: 5 pages, 4 figures, uses aipproc.sty, to appear in Proceedings of the Fifth Compton Symposiu

The optical light curve of GRB 970228 refined

We present the R and V light curves of the optical counterpart of GRB 970228. A critical analysis of all the available data is made in light of the results achieved in the recent GRB Symposium held in Huntsville and by considering the latest information from the HST images on the underlying nebulosity.Comment: 3 pages, 2 .ps figures, Nuclear Physics style file espcrc2.sty included. To appear in the proceedings of the conference "The Active X-Ray Sky: Results from BeppoSAX and Rossi-XTE", Rome, Italy, 21-24 October, 1997. L. Scarsi, H. Bradt, P. Giommi and F. Fiore editors, Nuc. Phys. B Proc. Supp

PG 1613+426: a new sdB pulsator

We report the detection of short period oscillations in the hot subdwarf B (sdB) star PG 1613+426 from time-series photometry carried out with the 91-cm Cassegrain telescope of the Catania Astrophysical Observatory. This star, which is brighter than the average of the presently known sdB pulsators, with B = 14.14 mag, has $T_{\rm eff}=34 400 {\rm K}$ and $\log g = 5.97$, its position is near the hot end of the sdB instability strip, and it is a pulsator with a well observed peak in the power spectrum at $144.18\pm 0.06 \rm s$. This star seems to be well suited for high precision measurements, which could detect a possible multi-mode pulsation behaviourComment: 3 pages, 4 figures. to appear on A&